Valvular & structural heart disease
Influence of age and sex on left ventricular remodelling in chronic aortic regurgitation
Authors' conclusion
Conventional parameters used to grade AR severity and LV remodelling are significantly influenced by age and sex. This encourages the use of age- and sex-specific volumetric thresholds for LV dilation monitoring and surgical referral in AR patients.
Study context
- Population
- Adult patients with chronic at least moderate aortic regurgitation (AR) by echocardiography, enrolled between 2003 and 2022, undergoing comprehensive cardiac magnetic resonance (CMR)consecutive adult patients (mean age 51 ± 16 years, 19% women)
- Participants
- 290 patients
- Exposure
- Impact of sex and age on left ventricular (LV) remodelling in chronic AR using CMR
- Outcome
- Correlation between RF and RVol
Methodological detailsconsecutive adult patients
- Consecutive adult patients
Main finding
As reported in the abstract
- Age and sex dependent; absolute and body surface indexed regurgitant volumes (RVol) represented a higher regurgitant fraction (RF) in women and older patients
Observational data: associations, not effects.
Further findings
LV volumes (LV-EDVi, LV-ESVi)
- Women had less dilated ventricles; LV-EDVi and LV-ESVi increased less with increasing AR severity in females and with advancing age
- LV volumes and RVol underestimated AR severity by RF in such patients
LV diameters and shape
- Women had larger LV diameters and more spherical ventricles; LV diameters failed to accurately identify severe AR among females as opposed to males
Age- and sex-specific LV volume thresholds
- Could equally assess AR severity across sexes
Original publication
Influence of age and sex on left ventricular remodelling in chronic aortic regurgitation. Eur Heart J Cardiovasc Imaging. Published 19 April 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →