Valvular & structural heart diseaseResearch article
Gender differences in clinical phenotype, right-heart remodelling and outcomes in severe tricuspid regurgitation: a cardiac magnetic resonance study
- cardiac magnetic resonance study
- five tertiary hospitals
- inverse probability of treatment weighting
- propensity score matching
Authors' conclusion
Women with severe TR exhibited fewer comorbidities, predominantly atrial TR, less RV remodelling, and better long-term survival compared with men. Sex-specific phenotyping may improve risk stratification and support more individualized therapeutic strategies.
Study context
- Population
- Patients with at least severe tricuspid regurgitation (TR) assessed by echocardiography who subsequently underwent cardiac magnetic resonance (CMR)mean age 71 ± 11 years, 67% women
- Participants
- 326 patients
- Comparison
- sex-related differences in clinical presentation, right ventricular (RV) remodelling assessed by cardiac magnetic resonance (CMR), and all-cause mortality
- Outcome
- All-cause mortality under medical therapy
- Follow-up
- Up to 10 years (median 35 months; IQR 12-60)
Main finding
As reported in the abstract
Men vs WomenHazard ratio (CI)P value
multivariable analysis after inverse probability of treatment weighting
2.08(1.30–3.33)
P = 0.002after propensity score matching
1.81(1.04–3.15)
P = 0.036Further findings
Tricuspid valve intervention · similar
P = 0.53
Comorbidities
- Women had a lower prevalence of diabetes, coronary artery disease, and chronic kidney disease
- all P < 0.05
TR aetiology
- Atrial functional TR more prevalent in women, ventricular TR predominated in men
- P < 0.05
CMR right-heart remodelling
- Women: lower indexed RV and right atrial volumes and higher right ventricular ejection fraction
- P < 0.01
Original publication
Gender differences in clinical phenotype, right-heart remodelling and outcomes in severe tricuspid regurgitation: a cardiac magnetic resonance study. Eur Heart J Cardiovasc Imaging. Published 16 April 2026. doi:10.1093/ehjci/jeag078
Summarised from the published abstract; every number is checked against it