Arrhythmias & electrophysiology
Influence of age and sex on the diagnostic yield of inherited cardiac conditions in sudden arrhythmic death syndrome decedents
Authors' conclusion
After a SADS death, the diagnostic yield of comprehensive FE, MA, or both in an expert setting can be up to 45% with a combined approach. Females had higher diagnostic yield than males, most notable with LQTS. CPVT and LQTS diagnoses declined with increasing age.
Study context
- Population
- Sudden arrhythmic death syndrome (SADS) decedents referred for familial evaluation (FE), molecular autopsy (MA) or both66% male
- Participants
- 760 decedents
- Exposure
- Diagnostic yield of FE and MA by age and sex
- Outcome
- Diagnostic yield for an inherited cardiac condition, by age and sex
Methodological detailssingle-centre, consecutive referrals, Bayesian analysis
- Single-centre
- Consecutive referrals
- Bayesian analysis
Main finding
As reported in the abstract
Overall diagnostic yield for an inherited cardiac condition
Observational data: associations, not effects.
Further findings
| Outcome | RR (CI) | |
|---|---|---|
| FE diagnosis of LQTSvs remaining unexplained, per year increase in ageDeclined by 5.6% | 0.94 (0.91–0.98) | |
| FE diagnosis of CPVTvs remaining unexplained, per year increase in ageDeclined by 11% | 0.89 (0.81–0.97) | |
| 0.512Relative risk (log scale) |
| Outcome | Females | Males |
|---|---|---|
| Diagnostic yield by sex, FE | 40% (interval 34–45%) | 36% (interval 31–41%) |
| Diagnostic yield by sex, MA | 15% (interval 10–21%) | 6% (interval 3–8%) |
| LQTS diagnosis by sex, MA cohort | 8.1% (interval 4.1–13.4%) | 1.2% (interval 0.2–2.7%) |
Original publication
Influence of age and sex on the diagnostic yield of inherited cardiac conditions in sudden arrhythmic death syndrome decedents. Eur J Prev Cardiol. Published 23 December 2024. doi:10.
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