Valvular & structural heart disease
Influence of cusp morphology and sex on quantitative valve composition in severe aortic stenosis
Authors' conclusion
In severe aortic stenosis, bicuspid valves have proportionately more fibrosis than tricuspid valves, especially in women.
Study context
- Population
- Patients with severe AS undergoing TAVI, valve composition quantified by contrast-enhanced CT angiographymatched by age, sex, comorbidities
- Participants
- 140 patients
- Exposure
- Bicuspid vs tricuspid aortic valves
- Bicuspidn = 70
- Tricuspidn = 70reference
- Outcome
- Fibrotic and calcific scores (volume/valve annular area) and fibro-calcific ratio
Methodological detailspropensity-score matched 1:1
- Propensity-score matched 1:1
Main finding
As reported in the abstract
Fibrotic score
P = 0.006
- Calcific scores similar between bicuspid and tricuspid
- P = 0.614
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Fibrotic score, women vs men (subgroup)Women vs Men · bicuspid: 224 (181-307) vs 169 (109-247) | P = 0.042 |
| Fibrotic score, women vs men (subgroup)Women vs Men · tricuspid: not greater | P = 0.232 |
| Calcific score, men vs women (subgroup)Men vs Women · bicuspid: 203 (124-355) vs 130 (70-182) | P = 0.008 |
| Calcific score, men vs women (subgroup)Men vs Women · tricuspid: 177 (136-249) vs 100 (62-150) | P = 0.004 |
| Fibro-calcific ratio, women vs men (subgroup)Women vs Men · tricuspid: 1.86 (0.94-2.56) vs 0.86 (0.54-1.24) | P = 0.001 |
| Fibro-calcific ratio, women vs men (subgroup)Women vs Men · bicuspid: 1.78 (1.21-2.90) vs 0.74 (0.44-1.53) | P = 0.001 |
Original publication
Influence of cusp morphology and sex on quantitative valve composition in severe aortic stenosis. Eur Heart J Cardiovasc Imaging. Published 20 June 2023. doi:10.
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