Influence of left ventricular ejection fraction in patients undergoing contemporary pLVAD-supported high-risk percutaneous coronary intervention (PCI)
Primary result · 90-day MACCEResult — go to the resultAdj.HR per 5% 0.89 95% CI 0.80–0.98Authors' conclusion
Patients who underwent pLVAD-supported HRPCI exhibited low incidence of PCI-related complications, regardless of baseline LVEF. However, LVEF was associated with 90-day MACCE and 1-year mortality.
Study context
- Population
- Patients from the PROTECT III study undergoing pLVAD-supported high-risk PCI, March 2017 to March 2020evaluable baseline LV ejection fraction (LVEF)
- Participants
- 940 patients
- Comparison
- Outcomes by baseline LVEF category in pLVAD-supported high-risk PCI
- Primary endpoint
- MACCE:
- All-cause death
- MI
- Stroke/TIA
- Repeat revascularization
- Follow-up
- 90 days
Primary result
90-day MACCE
Adj.HR per 5%
0.89
95% CI 0.80–0.98
P = 0.018
LVEF (continuous, per 5%)
adj.HR per 5% 0.89 (95% CI 0.80–0.98); P = 0.018
Per 5%, as printed
As reported in the abstract
Further findings
| Outcome | adj.HR per 5% (CI) | P value | |
|---|---|---|---|
| 1-year mortality | 0.84 (0.78–0.90) | P < 0.0001 | |
| 0.512Adj.HR per 5% (log scale) |
Safety
Immediate PCI-related coronary complications
- Overall incidence
- 2.7%
- Similar between groups, not associated with LVEF
- P = 0.98
Original publication
Influence of left ventricular ejection fraction in patients undergoing contemporary pLVAD-supported high-risk PCI. Am Heart J. Published 26 December 2023. doi:10.
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