Influence of multiple risk factor control level on cardiovascular outcomes in hypertensive patients
Authors' conclusion
A stepwise association was observed between cardiovascular risk and the number of risk factor control in hypertensive patients. The more risk factors were modified, the less cardiovascular risk was observed, irrespective of different blood pressure lowering strategies.
Study context
- Population
- Elderly hypertensive patients in the STEP trial with complete baseline risk factor data
- Participants
- 8,337 patients
- Comparison
- Risk factor control levels
- Primary endpoint
- Composite of:
- CV events
- All-cause mortality
- Follow-up
- Median 3.19 years
Primary result
As reported in the abstract
Hazard ratio (95% CI)
Each additional uncontrolled risk factor24% higher CV risk
1.24(1.11–1.37)
≤3vs ≥695% higher CV risk
1.95(1.37–2.77)
Further findings
Effect of risk factor control by intensive vs standard antihypertensive treatment (subgroup)
- Not influenced by intensive or standard antihypertensive treatment
- P for interaction = 0.71
Original publication
Influence of multiple risk factor control level on cardiovascular outcomes in hypertensive patients. Eur Heart J Qual Care Clin Outcomes. Published 11 July 2024. doi:10.
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