Coronary disease & ACSCohort study
Influence of Pullback Pressure Gradient on Residual Angina at One Year
- prospective, investigator-initiated, single-arm, multicenter study
Authors' conclusion
In patients with flow-limiting coronary artery disease, a focal disease pattern defined by high PPG was associated with greater symptomatic relief at 1 year compared with diffuse disease (low PPG). By capturing the underlying pathophysiologic distribution of epicardial disease and its relation to post-treatment symptom relief, PPG may support a more tailored revascularization decision-making and percutaneous coronary intervention strategy.
Study context
- Population
- Patients with at least 1 lesion with a fractional flow reserve ≤0.80 intended to be treated with percutaneous coronary interventionpatients with pullback pressure gradient (PPG) and the Seattle Angina Questionnaire at 1 year
- Participants
- 947 patients
- Exposure
- focal coronary artery disease versus diffuse disease
Main finding
As reported in the abstract
focal coronary artery disease
95.3
mean · SD 9.9
diffuse disease
92.5
mean · SD 15.0
P = 0.006
Observational data: associations, not effects.
Further findings
Improvement in angina
- PPG independently associated with improvement in angina
- P = 0.017
Baseline characteristics
- mean age
- 67.6±10.2 years
- female
- 24%
- diabetes
- 29%
Original publication
Summarised from the published abstract; every number is checked against it