Rationale and design of the pullback pressure gradient (PPG) global registry
Authors' conclusion
This international, large-scale, prospective study with pre-specified powered hypotheses will determine the ability of the preprocedural PPG index to predict optimal revascularization assessed by post-PCI FFR.
Study context
- Population
- Patients with ≥1 lesion in a major epicardial vessel with distal fractional flow reserve (FFR) ≤ 0.80 intended for PCIplanned
- Participants
- 982 patients
- Outcome
- Predictive capacity of pre-PCI PPG for post-PCI FFR (optimal PCI result: post-PCI FFR ≥ 0.88; hypothesised AUC ≥ 0.80)
Methodological detailsstudy design and rationale, controlled, investigator-initiated, international, Clinical follow-up up to 36 months; events adjudicated by independent clinical event committee
- Study design and rationale
- Controlled
- Investigator-initiated
- International
- Clinical follow-up up to 36 months; events adjudicated by independent clinical event committee
Main finding
As reported in the abstract
- Recruitment ongoing, expected completion second half of 2023; no results reported
Observational data: associations, not effects.
Original publication
Rationale and design of the pullback pressure gradient (PPG) global registry. Am Heart J. Published 21 August 2023. doi:10.
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