Heart failure & cardiomyopathies
Influence of Serum Transferrin Concentration on Diagnostic Criteria for Iron Deficiency in Chronic Heart Failure
Authors' conclusion
Many patients with CHF and a low STC have low SIC even when TSAT is >20% and serum ferritin >100 μg/L; such patients have a high prevalence of anaemia and a poor prognosis and might have iron deficiency but are currently excluded from clinical trials of iron repletion.
Study context
- Population
- Patients with chronic HF attending a clinic serving a large local population
- Participants
- 4,422 patients
- Exposure
- Low vs higher serum transferrin concentration
- Outcome
- Relationship of STC to clinical characteristics, markers of iron deficiency and inflammation, and mortality
Main finding
As reported in the abstract
Mortality (adjusted for age, NT-proBNP and haemoglobin)
Hazard ratio (95% CI)
Higher SIC
0.87(0.81–0.95)
Higher STC
0.82(0.73–0.91)
- Lowest STC quartile: SIC ≤13 μmol/L
- 624 (52%)
- Of these, transferrin saturation (TSAT) ≥20%
- 38%
- Highest STC quartile: TSAT <20% with SIC >13 μmol/L
- 185 (17%)
- STC correlation with ferritin
- r = −0.52
- STC correlation with hs-CRP
- r = −0.17
- STC correlation with albumin
- r = 0.29
Observational data: associations, not effects.
Original publication
Influence of Serum Transferrin Concentration on Diagnostic Criteria for Iron Deficiency in Chronic Heart Failure. ESC Heart Fail. Published 3 July 2023. doi:10.
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