Heart failure & cardiomyopathies
Applicability of New Proposed Criteria for Iron Deficiency in Japanese Patients with Heart Failure
Authors' conclusion
When defined by the proposed criteria and not the guideline criteria, ID was associated with higher mortality in patients with chronic HF, suggesting that the proposed ID criteria is applicable to the Japanese population.
Study context
- Population
- Japanese patients with chronic heart failure (HF)
- Participants
- 763 patients
- Exposure
- Proposed iron deficiency (ID) criteria vs guideline ID criteria
- Proposed ID criterian = 213
- Guideline ID criterian = 444
- Outcome
- All-cause mortality
- Follow-up
- Median 436 days (IQR 297-565)
Methodological detailsmulticentre registry
- Multicentre registry
Main finding
As reported in the abstract
Hazard ratio (95% CI)
Proposed ID criteria
2.01(1.16–3.51)
Guideline ID criteria
1.32(0.76–2.28)
- All-cause mortality, overall
- 56 (7%)
- No significant difference with vs without guideline ID
- P = 0.32
- Higher mortality with serum iron ≤10 μmol/L
- P = 0.002
Observational data: associations, not effects.
Original publication
Applicability of New Proposed Criteria for Iron Deficiency in Japanese Patients with Heart Failure. ESC Heart Fail. Published 10 December 2022. doi:10.
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