Arrhythmias & electrophysiologyCohort study
Insights from 10-year follow-up of His bundle pacing: A multicenter experience
- retrospective multicenter study
- consecutive patients
- 2 high-volume centers
Authors' conclusion
This large multicenter experience demonstrates that HBP is a safe and effective pacing strategy with durable performance, acceptable device longevity, and stable ventricular function over a decade of follow-up. Technical issues-primarily threshold rise-are generally manageable. These findings provide the longest longitudinal data to date supporting HBP as a reliable physiological pacing modality.
Study context
- Population
- Patients who underwent successful permanent His bundle pacing between 2003 and 2013consecutive patients with successful his bundle pacing (HBP), follow-up data available for 487, 193 completed ≥10 years of follow-up
- Participants
- 500 patients
Main finding
As reported in the abstract
Selective HBP
51%
Observational data: associations, not effects.
Further findings
Battery depletion · 10 years
- Battery depletion
- 66.6%
Device longevity, backup leads
- Backup leads associated with reduced device longevity, hazard ratio
- 1.87; P < .001
Left ventricular ejection fraction (LVEF)
- ≥5% improvement in LVEF, particularly among those with a baseline LVEF of <45%
- 30.7%
- Overall, LVEF remained stable
All-cause mortality
- All-cause mortality, predominantly noncardiac
- 38.2%
Follow-up
- Follow-up data available
- 487 patients
- mean age
- 75 ± 9 years
- mean duration
- 7.9 ± 4.7 years
- completed ≥10 years of follow-up
- 193 patients
Safety
Lead-related events
- Lead-related events
- 12.1%
- capture threshold rise
- 10.5%
- lead dislodgment
- 0.8%
Original publication
Summarised from the published abstract; every number is checked against it