Arrhythmias & electrophysiology
Questioning the role of pulmonary vein isolation in multimorbid patients: A prospective analysis in more than 1400 atrial fibrillation (AF) patients
Main finding · Recurrence of any atrial arrhythmiaResult — go to the resultHazard ratio 1.26 95% CI 1.03–1.53Authors' conclusion
Despite the established prognostic benefit of ERC in multimorbid patients, long-term rhythm control with PVI is significantly less effective in this population.
Study context
- Population
- Patients with AF undergoing first-time cryoballoon-based pulmonary vein isolation
- Participants
- 1,402 patients
- Exposure
- High vs low comorbidity burden in patients undergoing cryoballoon pulmonary vein isolation (PVI)
- Outcome
- Recurrence of any atrial arrhythmia after a 90-day blanking period
- Follow-up
- 5 years
Methodological detailssingle-centre, consecutive patients
- Single-centre
- Consecutive patients
Main finding
Recurrence of any atrial arrhythmia
Hazard ratio
1.26
95% CI 1.03–1.53
P = 0.01
By group
High comorbidity burdenvs Low comorbidity burden
HR 1.26 (95% CI 1.03–1.53); P = 0.01
As reported in the abstract
Observational data: associations, not effects.
Secondary outcomes
- Age ≥75 years was the only independent predictor of recurrence
Safety
Safety outcomes and procedural safety
- Similar across groups
Original publication
Questioning the role of pulmonary vein isolation in multimorbid patients: A prospective analysis in more than 1400 AF patients. Heart Rhythm. Published 10 October 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →