Interleukin-6 and Cardiovascular Events in Healthy Adults: MESA
Authors' conclusion
High levels of circulating IL-6 are associated with worse CV outcomes and increased all-cause mortality consistently across all racial and ethnic groups.
Study context
- Population
- Adults without baseline cardiovascular disease (CVD) from four racial and ethnic groups (MESA)
- Participants
- 6,622 adults
- Exposure
- IL-6 tercile 3 vs tercile 1
- Outcome
- CVD events:
- All-cause mortality
- CV mortality
- HF
- Non-CV mortality
Methodological detailsmulticenter, community-based, observational analysis of MESA
- Multicenter
- Community-based
- Observational analysis of MESA
Main finding
As reported in the abstract
Adjusted risk, IL-6 tercile 3 vs tercile 1
Tercile 3 vs Tercile 1Hazard ratio (95% CI)
All-cause mortality
1.98(1.67–2.36)
CV mortality
1.55(1.05–2.30)
non-CV mortality
2.05(1.65–2.56)
HF
1.48(0.99–2.19)
Observational data: associations, not effects.
Further findings
IL-6 as a continuous variable
- Higher IL-6 associated with increased risk of all individual outcomes
All outcomes by race and ethnicity vs non-Hispanic White
- Unadjusted and adjusted risk similar across all IL-6 terciles
Original publication
Interleukin-6 and Cardiovascular Events in Healthy Adults: MESA. JACC Adv. Published 9 July 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →