Intermittent Fasting After ST-Segment–Elevation Myocardial Infarction Improves Left Ventricular Function: The Randomized Controlled INTERFAST-MI Trial
Authors' conclusion
Our results suggest that intermittent fasting after myocardial infarction may be safe and could improve left ventricular function after STEMI.
Study context
- Population
- Patients after STEMIITT: 22 + 20 analysed
- Participants
- 48 patients
- Comparison
- Intermittent fasting vs regular diet
- Intermittent fastingn = 24
- Regular dietn = 24reference
- Primary endpoint
- Improvement in LVEF
- Follow-up
- 4 weeks
Methodological detailsprospective, nonblinded, single-center, investigator-initiated, Randomised October 1, 2020, to July 15, 2022; followed for 6 months with visits at 4 weeks and 3 months
- Prospective
- Nonblinded
- Single-center
- Investigator-initiated
- Randomised October 1, 2020, to July 15, 2022; followed for 6 months with visits at 4 weeks and 3 months
Primary result
As reported in the abstract
Intermittent fasting
6.636
mean · SD 7.122 · %
Regular diet
1.450
mean · SD 4.828 · %
P = 0.038
Further findings
- Adherence to intermittent fasting
- 83.7% · median · IQR 69.0%–98.4% · of all days
Improvement in LVEF · 3 and 6 months
- Effect still significant and even more pronounced
DBP and body weight
- Greater reduction in DBP and body weight with intermittent fasting vs control
Safety
- None of the patients from either group reported dizziness, syncope or collapse
- 0
Original publication
Intermittent Fasting After ST-Segment–Elevation Myocardial Infarction Improves Left Ventricular Function: The Randomized Controlled INTERFAST-MI Trial. Circ Heart Fail. Published 2 May 2024. doi:10.
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