Value of dynamic computed tomography myocardial perfusion in coronary artery disease (CAD): a systematic review and meta-analysis
An erratum to this article was published (Eur Heart J Cardiovasc Imaging, 27 Nov 2024 ↗)
Authors' conclusion
Dynamic CT perfusion has high diagnostic performance in the quantitative assessment of ischaemia and detection of functional myocardial ischaemia as defined by invasive FFR and may be useful in risk stratification of CAD patients.
Study context
- Population
- Patients evaluated for functionally significant CAD23 studies
- Comparison
- Dynamic stress computed tomography (CT) perfusion vs invasive FFR as reference
- Outcome
- Diagnostic accuracy of dynamic CT perfusion for functionally significant ischaemia by invasive FFR (sROC)
Methodological detailsSearched PubMed, Embase, Web of Science and Cochrane library
- Searched PubMed, Embase, Web of Science and Cochrane library
Pooled result
As reported in the abstract
Detection of functionally significant ischaemia (patient-based)
| Group | AUC (summary receiver operating characteristic (sROC)) | Sensitivity | Specificity |
|---|---|---|---|
| CT-MBF | 0.92 | 0.82 | 0.86 |
CT-MBF
AUC (summary receiver operating characteristic (sROC))0.92
Sensitivity0.82
Specificity0.86
Further pooled results
MBF in myocardial regions without vs with ischaemia
P < 0.001
Prediction of adverse events by dynamic CT perfusion
| Pooled HR (95% CI) | P value | ||
|---|---|---|---|
| Dynamic CT perfusionI2 = 61%, P for heterogeneity = 0.07 | 4.98 (2.08–11.93) | P ≤ 0.001 | |
| 0.050.21520Pooled hazard ratio (log scale) |
Diagnostic performance by CT type (dual vs single source) and BMI
- CT type and BMI did not significantly affect diagnostic performance
Original publication
Value of dynamic computed tomography myocardial perfusion in CAD: a systematic review and meta-analysis. Eur Heart J Cardiovasc Imaging. Published 2 May 2024. doi:10.
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