Anxiety and depression and secondary prevention of coronary heart disease in 14 countries across six WHO regions: the INTERASPIRE study
Authors' conclusion
Increasing severity of depression and anxiety symptoms are associated with reduced potential for achieving guideline standards for CHD secondary prevention.
Study context
- Population
- Adults hospitalized in the preceding 6 to 24 months with incident or recurrent coronary heart disease (CHD), interviewed and examined 2020 to 2023 in 14 countries21.1% women
- Participants
- 4,546 adults
- Exposure
- Symptoms of anxiety and/or depression vs no symptoms
- Outcome
- Suboptimal INTERASPIRE-Guideline Target Score (GTS; 10-point assessment of achieving secondary prevention lifestyle, risk factor and therapeutic targets)
Methodological details14 countries across six WHO regions
- 14 countries across six WHO regions
Main finding
As reported in the abstract
Suboptimal INTERASPIRE-GTS
Each group vs no symptomsAdjusted odds ratio (95% CI)P value
Depression
1.52(1.13–2.04)
P = 0.006Possible comorbid anxiety and depression
1.57(1.09–2.26)
P = 0.015Probable comorbid anxiety and depression
2.09(1.22–3.57)
P = 0.007Observational data: associations, not effects.
Further findings
Prevalence of anxiety and/or depression by sex; CHD lifestyle and behavioural risk factors by symptom severity
- Prevalence of anxiety and/or depression greater in women than men
- Prevalence of CHD lifestyle and behavioural risk factors increased with severity of anxiety and depression symptoms
Original publication
Anxiety and depression and secondary prevention of coronary heart disease in 14 countries across six WHO regions: the INTERASPIRE study. Eur J Prev Cardiol. Published 13 November 2025. doi:10.
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