Interpretation of Elevated Baseline Concentrations and Serial Changes of High-Sensitivity Cardiac Troponin T in Confirmed Muscular Dystrophies
Authors' conclusion
The high prevalence of elevated hs-cTnT could negatively impact the effectiveness of rule-out and rule-in strategies based on a single hs-cTnT value.
Study context
- Population
- Stable outpatients with confirmed skeletal muscle dystrophies
- Participants
- 35 outpatients
- Outcome
- Baseline hs-cTnT and serial changes
Main finding
As reported in the abstract
- Values > 99th percentile upper limit of normal
- 34 of 35
- European Society of Cardiology (ESC) 0/1 h algorithm: rule-out (high-sensitivity cardiac troponin T (hs-cTnT) < limit of detection)
- 0
- ESC 0/1 h algorithm: rule-in (hs-cTnT ≥ 52 ng/L)
- 5
- Biological variability at 6-12 months per minimal important difference (MID)
- 1.2 ng/L (95% CI 0.7-2.1)
- Biological variability at 6-12 months per reference change value (RCV)
- 28.6% (95% CI 27.9-29.6)
- Cases exceeding biological variation range (MID; RCV)
- 8 (22.9%); 25 (71.4%)
Observational data: associations, not effects.
Safety
CV adverse events · follow-up 6.6 months (IQR: 6-7)
- All patients stable without CV adverse events
Original publication
Interpretation of Elevated Baseline Concentrations and Serial Changes of High-Sensitivity Cardiac Troponin T in Confirmed Muscular Dystrophies. ESC Heart Fail. Published 11 July 2024. doi:10.
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