High-Sensitivity Cardiac Troponin for Risk Assessment in Patients With Chronic Coronary Artery Disease
Main finding · MI or CV deathResult — go to the resultAdjusted hazard ratio 2.3 95% CI 1.7–3.0Authors' conclusion
In patients with chronic coronary artery disease, cardiac troponin predicts risk of myocardial infarction or cardiovascular death independent of cardiovascular risk factors and disease severity.
Study context
- Population
- Consecutive patients with symptoms suggestive of stable angina attending for outpatient coronary angiography; high-sensitivity cardiac troponin I measured before angiographyCAD in 3,888 (92%)
- Participants
- 4,240 patients
- Exposure
- Primary outcome event vs no event
- Eventn = 255
- Outcome
- Myocardial infarction or cardiovascular death
- Follow-up
- During
Methodological detailsconsecutive patients, clinicians blinded to troponin results
- Consecutive patients
- Clinicians blinded to troponin results
Main finding
MI or CV death · median follow-up 2.4 years (IQR: 1.3-3.6 years)
Adjusted hazard ratio
2.3
95% CI 1.7–3.0
P < 0.001
By group
Primary outcome eventvs no event (troponin concentrations)
adjusted HR 2.3 (95% CI 1.7–3.0); P < 0.001
As reported in the abstract
- Primary outcome events in patients with CAD
- 255 (6%)
- Troponin concentrations 2-fold higher with an event than without
- P < 0.001
Observational data: associations, not effects.
Original publication
High-Sensitivity Cardiac Troponin for Risk Assessment in Patients With Chronic Coronary Artery Disease. J Am Coll Cardiol. Published 8 August 2023. doi:10.
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