Serial troponin-I and long-term outcomes in subjects with suspected acute coronary syndrome
Authors' conclusion
Among individuals with suspected ACS, those with a persistently elevated hsTnI concentration consistently had the highest risk of death. In subjects with two normal hsTnI concentrations, mortality was very low and not affected by the magnitude of change between measurements.
Study context
- Population
- Individuals with suspected acute coronary syndrome (ACS) with two high-sensitivity troponin-I (hsTnI) measurements 1–7 h apart during a first-time hospitalization for MI, unstable angina, observation for suspected MI or chest pain, Denmark, 2012–2019
- Participants
- 20,609 individuals
- Exposure
- hsTnI concentration patterns and magnitude of change
- Outcome
- All-cause mortality (standardized risk of death)
- Follow-up
- 0-30 days and 31-365 days
Methodological detailsDanish national registries, standardized risks
- Danish national registries
- Standardized risks
Main finding
As reported in the abstract
Standardized risk of death
| Outcome | Normal | Persistently elevated |
|---|---|---|
| 0-30 days | 0.5% | 8.0% |
| 31-365 days | 2.6% | 11.1% |
Observational data: associations, not effects.
Further findings
| Outcome | >50% rise | Less pronounced rise |
|---|---|---|
| 30-day mortality, rising pattern, by magnitude of rise (subgroup) | 2.2% | <0.1% |
Effect of relative hsTnI change (normal and persistently elevated patterns)
- Relative hsTnI change did not clearly affect mortality risk
Original publication
Serial troponin-I and long-term outcomes in subjects with suspected acute coronary syndrome. Eur J Prev Cardiol. Published 6 December 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →