Intravascular Imaging–Guided Optimization of Complex Percutaneous Coronary Intervention by Sex: A Subgroup Analysis of the RENOVATE-COMPLEX-PCI Trial
Authors' conclusion
In patients undergoing complex PCI, compared with angiographic guidance, intravascular imaging guidance was associated with similar reduction in the risk of target vessel failure among women and men.
Study context
- Population
- Patients with complex coronary artery lesions undergoing PCI, Korea, enrolled May 2018–May 2021339 (20.7%) women
- Participants
- 1,639 patients
- Comparison
- Intravascular imaging-guided PCI vs angiography-guided PCI, by sex
- Primary endpoint
- Target vessel failure:
- Cardiac death
- Target vessel-related MI
- Clinically driven target vessel revascularization
- Follow-up
- Median 2.1 years
Methodological detailsprespecified substudy, investigator-initiated, open-label, multicentre, 20 sites in Korea, 2:1 randomisation, Data analysed December 2022–December 2023
- Prespecified substudy
- Investigator-initiated
- Open-label
- Multicentre
- 20 sites in Korea
- 2:1 randomisation
- Data analysed December 2022–December 2023
Primary result
As reported in the abstract
Target vessel failure, by sex (subgroups)
Intravascular imaging-guided PCI
- Women
- 5.2%
- Men
- 8.3%
Angiography-guided PCI
- Women
- 14.5%
- Men
- 11.7%
Women
Intravascular imaging-guided PCI5.2%
Angiography-guided PCI14.5%
Men
Intravascular imaging-guided PCI8.3%
Angiography-guided PCI11.7%
Intravascular imaging-guided PCI vs Angiography-guided PCIAdjusted hazard ratio (95% CI)P value
Women
0.34(0.15–0.78)
P = 0.01Men
0.72(0.49–1.05)
P = 0.09Secondary outcomes
| Outcome | Adjusted HR (95% CI) | P value | |
|---|---|---|---|
| Target vessel failure, womenvs men9.4% vs 8.3% | 1.39 (0.89–2.18) | P = 0.15 | |
| 0.512Adjusted hazard ratio (log scale) |
Original publication
Intravascular Imaging–Guided Optimization of Complex Percutaneous Coronary Intervention by Sex: A Subgroup Analysis of the RENOVATE-COMPLEX-PCI Trial. JAMA Cardiol. Published 1 May 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →