Joint Exposure to Ozone and Temperature and Acute Myocardial Infarction Among Adults Aged 18 to 64 Years in the United States
Authors' conclusion
Joint exposure to ozone pollution and high temperature increased the probability of AMI among younger adults, even when one of the exposures was moderate.
Study context
- Population
- Adults aged 18 to 64 years with incident acute myocardial infarction (AMI), nationwide private insurance, contiguous US, 2016–2020
- Participants
- 270,123 adults
- Comparison
- Joint ozone-temperature exposures vs reference
- Outcome
- Incident AMI
- Follow-up
- Lag 0 day
Methodological details2-stage model, multivariate random-effects meta-analysis of climate region-specific estimates
- 2-stage model
- Multivariate random-effects meta-analysis of climate region-specific estimates
Pooled result
As reported in the abstract
Increase (95% CI)
Ozone 60 ppb, temperature 95th percentile vs Ozone 35 ppb, temperature 1st percentile
33%(16%–51%)
Ozone 50 ppb, temperature median vs Ozone 35 ppb, temperature 1st percentile
15%(4%–28%)
Further pooled results
Incident AMI, by sex (subgroup)
- Heterogeneity by sex: women had increased odds when both ozone and temperature were high; men when either was high
Original publication
Joint Exposure to Ozone and Temperature and Acute Myocardial Infarction Among Adults Aged 18 to 64 Years in the United States. Circulation. Published 3 June 2025. doi:10.
Summarised from the published abstract; every number is checked against it