Valvular & structural heart disease
Prognostic significance and clinical utility of left atrial reservoir strain in transcatheter aortic valve replacement
Main findingResult — go to the resultHazard ratio 0.62 95% CI 0.44–0.86Authors' conclusion
Impaired LARS is independently associated with worse outcomes in patients undergoing TAVR.
Study context
- Population
- Consecutive patients undergoing transcatheter aortic valve replacement (TAVR) for aortic stenosis (AS), January–December 2018, with discharge echocardiography and follow-up53% women
- Participants
- 606 patients
- Exposure
- Left atrial reservoir strain (LARS) tertiles
- Outcome
- Composite of:
- All-cause death
- Readmission for worsening HF
- Follow-up
- 12 months after TAVR
Methodological detailsconsecutive patients
- Consecutive patients
Main finding
As reported in the abstract
Hazard ratio
0.62
95% CI 0.44–0.86
P = 0.005
By group
LARS tertiles
HR 0.62 (95% CI 0.44–0.86); P = 0.005
- Difference across tertiles
- P < 0.0001
Observational data: associations, not effects.
Further findings
Primary endpoint predictor: higher degree of tricuspid regurgitation
| HR (95% CI) | P value | ||
|---|---|---|---|
| Higher degree of tricuspid regurgitationAdjusted multivariable Cox regression | 1.82 (1.23–2.98) | P = 0.003 | |
| 0.20.5125Hazard ratio (log scale) |
Primary endpoint, subgroups without diastolic dysfunction (DD) assessment (DD unavailable in 56%)
| HR (95% CI) | P value | ||
|---|---|---|---|
| LARS | 0.64 (0.47–0.87) | P = 0.003 | |
| 0.512Hazard ratio (log scale) |
Original publication
Prognostic significance and clinical utility of left atrial reservoir strain in transcatheter aortic valve replacement. Eur Heart J Cardiovasc Imaging. Published 20 October 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →