Heart failure & cardiomyopathies
Left ventricular global longitudinal strain as a prognosticator in hypertrophic cardiomyopathy with a low-normal left ventricular ejection fraction
Authors' conclusion
LV-GLS was an independent predictor of a composite of cardiovascular death, including SCD/SCD-equivalent events, in patients with HCM and an LVEF of 50-60%.
Study context
- Population
- Patients with hypertrophic cardiomyopathy (HCM) and LV ejection fraction (LVEF) of 50–60%mean age 59.2 ± 14.2 years, men 75.6%
- Participants
- 349 patients
- Exposure
- Absolute LV-GLS ≤10.5% vs >10.5%
- Outcome
- Composite of:
- CV death
- Including SCD
- SCD-equivalent events
- Follow-up
- Median 4.1 years
Main finding
As reported in the abstract
Primary composite outcome
Adjusted hazard ratio (95% CI)P value
Absolute LV-GLS (per %)continuous; adjusted for age, AF, ischaemic stroke, LVEF, left atrial volume index
0.88(0.788–0.988)
P = 0.029LV-GLS ≤ 10.5%vs LV-GLS > 10.5%10.5% optimal cut-off by ROC analysis
2.54(1.117–5.787)
P = 0.026- Primary outcome occurred (whole cohort)
- 26 (7.4%)
Observational data: associations, not effects.
Secondary outcomes
Sudden cardiac death (SCD)/SCD-equivalent events, CV death, all-cause death · median follow-up 4.1 years
- SCD/SCD-equivalent events (whole cohort)
- 15 (4.2%)
- CV death (whole cohort)
- 20 (5.7%)
- All-cause death (whole cohort)
- 34 (9.7%)
- Absolute LV-GLS ≤ 10.5% independent predictor of each secondary outcome
- P < 0.05
Original publication
Left ventricular global longitudinal strain as a prognosticator in hypertrophic cardiomyopathy with a low-normal left ventricular ejection fraction. Eur Heart J Cardiovasc Imaging. Published 19 July 2023. doi:10.
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