Heart failure & cardiomyopathies
Left ventricular volume and maximal functional capacity in heart failure with preserved ejection fraction: Size matters
Authors' conclusion
In stable outpatients with HFpEF, a smaller iLVEDV was associated with a lower maximal functional capacity.
Study context
- Population
- Stable outpatients with heart failure with preserved ejection fraction (HFpEF) undergoing cardiopulmonary exercise testing and echocardiography on the same dayvalidation cohort, Milan
- Participants
- 133 outpatients
- Outcome
- Association between indexed LV end-diastolic volume (iLVEDV) and peak oxygen consumption (peakVO2)
Methodological detailsconsecutive outpatients, external validation cohort
- Consecutive outpatients
- External validation cohort
Main finding
As reported in the abstract
Association of iLVEDV with peakVO2 (adjusted linear regression)
- Smaller indexed left ventricular end-diastolic volume (iLVEDV) associated with lower peakVO2
- p = 0.0001
Observational data: associations, not effects.
Further findings
Reduced peakVO2, validation cohort (adjusted linear regression)
- Smaller iLVEDV associated with higher likelihood of reduced peakVO2
- P = 0.004
Baseline measures
- Median iLVEDV
- 46 ml/m² (30-56)
- Median peakVO2
- 11 ml/kg/min (9-13)
- Median % predicted peakVO2
- 64.1% (53-74.4)
Original publication
Left ventricular volume and maximal functional capacity in heart failure with preserved ejection fraction: Size matters. Eur J Heart Fail. Published 30 July 2024. doi:10.
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