Lifetime cumulative effect of reproductive factors on ischaemic heart disease in a prospective cohort
Authors' conclusion
Longer RLS, TEE and EEE were associated with lower risks of IHD among Chinese postmenopausal females.
Study context
- Population
- Postmenopausal females from the China Kadoorie Biobank, 2004–200813,162 (11.1%) developed ischaemic heart disease (IHD)
- Participants
- 118,855 females
- Exposure
- Lifetime oestrogen exposure quartiles: Q2–Q4 vs Q1
- Outcome
- Incident IHD
- Follow-up
- Median 8.9 years
Main finding
As reported in the abstract
Incident IHD by RLS, EEE and TEE quartile
Q1
- Reproductive lifespan (RLS) incidence
- 13.0 per 1000 person-years
- EEE incidence
- 15.8 per 1000 person-years
- TEE incidence
- 13.7 per 1000 person-years
Q2
- RLS incidence
- 12.1 per 1000 person-years
- EEE incidence
- 12.6 per 1000 person-years
- TEE incidence
- 12.3 per 1000 person-years
Q3
- RLS incidence
- 12.5 per 1000 person-years
- EEE incidence
- 11.3 per 1000 person-years
- TEE incidence
- 12.2 per 1000 person-years
Q4
- RLS incidence
- 13.8 per 1000 person-years
- EEE incidence
- 12.1 per 1000 person-years
- TEE incidence
- 13.4 per 1000 person-years
Reproductive lifespan (RLS) incidence
Q113.0 per 1000 person-years
Q212.1 per 1000 person-years
Q312.5 per 1000 person-years
Q413.8 per 1000 person-years
EEE incidence
Q115.8 per 1000 person-years
Q212.6 per 1000 person-years
Q311.3 per 1000 person-years
Q412.1 per 1000 person-years
TEE incidence
Q113.7 per 1000 person-years
Q212.3 per 1000 person-years
Q312.2 per 1000 person-years
Q413.4 per 1000 person-years
Adjusted hazard ratio (95% CI)
Q4vs Q1RLS
0.95(0.91–1.00)
Q4vs Q1TEE
0.92(0.88–0.97)
Q2vs Q1EEE
0.93(0.88–0.97)
Q3vs Q1EEE
0.88(0.84–0.93)
Q4vs Q1EEE
0.87(0.83–0.92)
Observational data: associations, not effects.
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Lifetime cumulative effect of reproductive factors on ischaemic heart disease in a prospective cohort. Heart. Published 18 October 2023. doi:10.
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