Lipoprotein(a) and Coronary Plaque in Asymptomatic Individuals: The Miami Heart Study at Baptist Health South Florida
Authors' conclusion
In this contemporary analysis, elevated Lp(a) was independently associated with the presence of coronary plaque.
Study context
- Population
- Asymptomatic adults aged 40 to 65 years without clinical atherosclerotic CVD, not taking lipid-lowering therapy, undergoing coronary CT angiography (Miami Heart Study)
- Participants
- 1,795 adults
- Exposure
- Lp ≥125 nmol/L vs Lp <125 nmol/L
- Lp(a) ≥125 nmol/Ln = 291
- Outcome
- Any plaque, CAC score >0, maximal stenosis ≥50%, any high-risk plaque feature, ≥2 high-risk plaque features
Methodological detailscommunity-based, baseline data
- Community-based
- Baseline data
Main finding
As reported in the abstract
Coronary plaque (multivariable)
Lp(a) ≥125 nmol/L vs Lp(a) <125 nmol/LOdds ratio (95% CI)
Any coronary plaque
1.40(1.05–1.86)
≥2 high-risk features; only 35 participants had this finding
3.94(1.82–8.52)
Observational data: associations, not effects.
Further findings
Any plaque among participants with CAC score 0 (subgroup, n=1200)
P < 0.001
Original publication
Lipoprotein(a) and Coronary Plaque in Asymptomatic Individuals: The Miami Heart Study at Baptist Health South Florida. Circ Cardiovasc Imaging. Published 16 July 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →