Coronary disease & ACS

Lipoprotein(a) and long-term in-stent restenosis after percutaneous coronary intervention

Eur J Prev CardiolPublished Retrospective cohort study

Main finding · ISRResult — go to the resultHazard ratio 1.67 95% CI 1.18–2.37

Authors' conclusion

Lipoprotein(a) is an independent predictor for long-term ISR

Study context

Population
Adults after successful percutaneous coronary intervention (PCI) with preprocedural Lp(a) measurement, 2006–2017
Participants
1,209 adults
Exposure
High Lp vs low Lp
Outcome
In-stent restenosis (ISR)
Follow-up
Median 8.8 years
Methodological details3 Mayo Clinic sites
  • 3 Mayo Clinic sites

Main finding

ISR

Hazard ratio

1.67

95% CI 1.18–2.37

P = 0.004

By group

High Lp(a)vs Low Lp(a)
HR 1.67 (95% CI 1.18–2.37); P = 0.004

As reported in the abstract

Observational data: associations, not effects.

Further findings

Serum Lp(a), ISR vs no ISR

P = 0.008

Overall in-stent restenosis (ISR)

Restenosis observed
162 (13.4%)

Original publication

Lipoprotein(a) and long-term in-stent restenosis after percutaneous coronary intervention. Eur J Prev Cardiol. Published 24 June 2024. doi:10.1093/eurjpc/zwae212

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