Coronary disease & ACSCohort study
Outcomes after coronary angiography in individuals with elevated lipoprotein(a)
- Cohort study
Authors' conclusion
Elevated Lp(a) levels are associated with increased burden of coronary atherosclerosis and significant residual risk for adverse outcomes following ICA
Study context
- Population
- Participants with Lp(a) measurement undergoing index invasive coronary angiography, 2000–2023
- Participants
- 5,118 participants
- Exposure
- Very high vs normal Lp
- Very highn = 973
- Outcome
- Acute myocardial infarction (AMI), revascularization, in-stent restenosis and all-cause mortality after index invasive coronary angiography (ICA)
- Follow-up
- Median 16.87 (IQR 6.38-18.99) years
Main finding
As reported in the abstract
Clinical outcomes after index ICA · median 16.87 years
Very high vs NormalAdjusted hazard ratio (95% CI)
AMI
1.20(1.05–1.37)
revascularization
1.32(1.13–1.56)
in-stent restenosis
1.28(1.04–1.56)
all-cause mortality
1.19(1.05–1.34)
Observational data: associations, not effects.
Further findings
| Outcome | Estimate | |
|---|---|---|
| Angiographic severity at index ICA — Very high vs Normal · severe obstructive CAD | aOR 1.51 (95% CI 1.17–1.96) | |
| Angiographic severity at index ICA — Very high vs Normal · left main disease | aOR 1.67 (95% CI 1.22–2.29) | |
| Subsequent PCI after CABG (subgroup, n = 798) | aHR 2.20 (95% CI 1.06–4.58) | |
| 0.20.5125Ratio (log scale) |
| Outcome | difference (Gensini score points) (95% CI) | |
|---|---|---|
| Angiographic severity at index ICA — Very high vs Normal · higher Gensini score | 14.04 (9.57–18.52) | |
| −1001020Difference, Gensini score points (linear scale) |
Original publication
Outcomes after coronary angiography in individuals with elevated lipoprotein(a). Eur J Prev Cardiol. Published 13 November 2025. doi:10.1093/eurjpc/zwaf690
Summarised from the published abstract; every number is checked against it