Long-term adiposity in early adulthood affects coronary artery calcification incidence in midlife: a 25-year longitudinal study
Main finding · CAC incidenceResult — go to the resultOdds ratio 2.52 95% CI 1.82–3.49Authors' conclusion
Greater cBRI from early adulthood was associated with an elevated risk of CAC incidence in mid-life.
Study context
- Population
- CARDIA study participants followed from young adulthood with body roundness index (BRI) at eight visits over 25 years
- Participants
- 2,102 participants
- Exposure
- Cumulative BRI (cBRI) quartiles
- Outcome
- Incident CAC (CAC > 0) by cardiac CT
- Follow-up
- Year 25 exam
Methodological details25-year longitudinal
- 25-year longitudinal
Main finding
CAC incidence · 25 years
Odds ratio
2.52
95% CI 1.82–3.49
cBRI quartiles (top vs lower)
OR 2.52 (95% CI 1.82–3.49)
As reported in the abstract
- Participants who developed coronary artery calcification (CAC) over 25-year follow-up
- 598
Observational data: associations, not effects.
Further findings
| Outcome | Estimate |
|---|---|
| All-cause mortality (higher cBRI)Multivariable Cox regression | 1.009 (95% CI 1.003–1.016) |
Original publication
Long-term adiposity in early adulthood affects coronary artery calcification incidence in midlife: a 25-year longitudinal study. Eur Heart J Cardiovasc Imaging. Published 15 August 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →