Liver Imaging in Fontan Patients: How Does Ultrasound Compare to Cross-Sectional Imaging?
Performance · Agreement for LC diagnosisResult — go to the resultKappa 0.21Authors' conclusion
Liver US is effective for screening and monitoring liver cirrhotic features in the adult Fontan population. In a univariate analysis, there was no association between LC and mortality or transplantation.
Study context
- Population
- Adults with Fontan circulation
- Participants
- 131 adults
- Comparison
- Liver ultrasound (US) vs cross-sectional imaging
- Outcome
- Diagnostic performance of US for detecting liver cirrhosis vs cross-sectional imaging
Methodological detailsretrospective
- Retrospective
Performance
Agreement for LC diagnosis
Kappa
0.21
By group
Liver US
- Heterogeneous parenchyma
- 85.4%
- Lobar redistribution
- 72.5%
- Surface nodularity
- 65.6%
- Sensitivity (all features)
- greater than 0.75
- Specificity, heterogeneous parenchyma
- 0.21
- Specificity, lobar redistribution
- 0.58
- Specificity, surface nodularity
- 0.85
- Liver cirrhosis (LC) diagnosed
- 78%
Cross-sectional imaging
- Heterogeneous parenchyma
- 60.3%
- Lobar redistribution
- 87.0%
- Surface nodularity
- 84.9%
- LC diagnosed
- 90%
Heterogeneous parenchyma
Liver US85.4%
Cross-sectional imaging60.3%
Lobar redistribution
Liver US72.5%
Cross-sectional imaging87.0%
Surface nodularity
Liver US65.6%
Cross-sectional imaging84.9%
Sensitivity (all features)
Liver USgreater than 0.75
Cross-sectional imaging— not stated in the abstract
Specificity, heterogeneous parenchyma
Liver US0.21
Cross-sectional imaging— not stated in the abstract
Specificity, lobar redistribution
Liver US0.58
Cross-sectional imaging— not stated in the abstract
Specificity, surface nodularity
Liver US0.85
Cross-sectional imaging— not stated in the abstract
Liver cirrhosis (LC) diagnosed
Liver US78%
Cross-sectional imaging90%
As reported in the abstract
Further findings
- No significant correlation between hepatic parenchymal changes or cirrhosis and mortality/transplantation
- Univariate Cox analysis
Original publication
Liver Imaging in Fontan Patients: How Does Ultrasound Compare to Cross-Sectional Imaging? JACC Adv. Published 23 October 2024. doi:10.
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