Arrhythmias & electrophysiology
Long Noncoding RNA UCA1 Correlates With Electropathology in Patients With Atrial Fibrillation
Authors' conclusion
LncRNAs SARRAH and LIPCAR are reduced in RAA of AF patients, and UCA1 levels correlate with electrophysiologic conduction abnormalities.
Study context
- Population
- Patients with paroxysmal or persistent atrial fibrillation (AF) and patients in sinus rhythm without AF; Long noncoding RNAs (lncRNAs) UCA1, SARRAH, LIPCAR measured by qRT-PCR in right atrial appendage and/or serum
- Participants
- 59 / 56 / 70
- Comparison
- Paroxysmal AF (ParAF) and persistent AF (PerAF) vs SR
- ParAFn = 59
- PerAFn = 56
- SRn = 70reference
- Outcome
- Association between 3 cardiac lncRNAs and the degree of electropathology
Methodological detailsSubset underwent high-resolution epicardial mapping during SR
- Subset underwent high-resolution epicardial mapping during SR
Main finding
As reported in the abstract
- SARRAH and LIPCAR expression decreased in right atrial appendage (RAA) of all AF patients vs SR
- RAA UCA1 levels correlated significantly with % conduction block and delay, and inversely with conduction velocity
Further findings
Serum SARRAH and UCA1 levels
- Increased in total AF group and ParAF vs SR
Original publication
Long Noncoding RNA UCA1 Correlates With Electropathology in Patients With Atrial Fibrillation. JACC Clin Electrophysiol. Published 24 May 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →