Long-term aspirin adherence following myocardial infarction and risk of cardiovascular events
Authors' conclusion
Non-adherence to long-term aspirin was associated with increased risk of MI, stroke, or death, but not in women or individuals >65 years. The risk decreased from 4 years after MI with near statistical significance.
Study context
- Population
- Patients ≥40 years with myocardial infarction (MI) 2004–2017, adherent to aspirin 1 year after MI
- Participants
- 40,116 patients
- Exposure
- Aspirin non-adherence vs continued adherence after MI
- Outcome
- Composite of:
- MI
- Stroke
- Death
- Follow-up
- 2 years from each time point (2, 4, 6, 8 years after MI)
Methodological detailsDanish nationwide registries, average treatment effect modelling
- Danish nationwide registries
- Average treatment effect modelling
Main finding
As reported in the abstract
MI, stroke, or death
Non-adherent vs AdherentRelative risk (95% CI)P value
4-6 years
1.41(1.27–1.55)
8-10 years
1.21(1.06–1.36)
P = 0.056for trendObservational data: associations, not effects.
Further findings
MI, stroke, or death by sex and age (subgroups)
- Non-adherence in women and individuals >65 years not associated with increased risk
- Interaction P, age at each time point: <0.001, <0.001, 0.002, 0.51
- Interaction P, sex at each time point: 0.25, 0.02, 0.02, 0.82
Original publication
Long-term aspirin adherence following myocardial infarction and risk of cardiovascular events. Eur Heart J Qual Care Clin Outcomes. Published 1 February 2024. doi:10.
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