Valvular & structural heart disease
Long-Term Clinical and Echocardiographic Outcomes Following the Ross Procedure: A Post Hoc Analysis of a Randomized Clinical Trial
Authors' conclusion
This study found that the Ross procedure provided excellent survival into the third decade postoperatively that was comparable to that in the general population.
Study context
- Population
- Adults (age <69 years) with aortic valve disease undergoing the Ross procedure, incl. active endocarditis, rheumatic AVD, decreased EF and previous cardiac surgery98% follow-up completeness
- Participants
- 108 adults
- Comparison
- Ross procedure vs age-, country of origin- and sex-matched general population
- Ross proceduren = 108
- Primary endpoint
- Long-term survival vs matched general population
- Follow-up
- 25 years
Methodological detailssingle-centre, retrospective data collection after 2010, Trial conducted September 1, 1994, to May 31, 2001; median clinical follow-up 24.1 years (IQR, 22.6-26.1 years; 2488 patient-years)
- Single-centre
- Retrospective data collection after 2010
- Trial conducted September 1, 1994, to May 31, 2001; median clinical follow-up 24.1 years (IQR, 22.6-26.1 years; 2488 patient-years)
Primary result
Survival
Relative survival
99.1%
95% CI 91.8%–100%
By group
As reported in the abstract
Secondary outcomes
Freedom from reintervention · 25 years
- Freedom from any reintervention
- 71.1% (95% CI, 61.6%-82.0%)
- Freedom from autograft reintervention
- 80.3% (95% CI, 71.9%-89.6%)
- Freedom from homograft reintervention
- 86.3% (95% CI, 79.0%-94.3%)
Outcomes after Ross-related reintervention
- 30-day mortality after first Ross-related reintervention
- 0%
- 30-day mortality after all Ross-related reinterventions
- 3.8% (n = 1)
- 10-year survival after reoperation
- 96.2% (95% CI, 89.0%-100%)
Original publication
Long-Term Clinical and Echocardiographic Outcomes Following the Ross Procedure: A Post Hoc Analysis of a Randomized Clinical Trial. JAMA Cardiol. Published 1 January 2024. doi:10.
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