Long-term incidence of infective endocarditis among patients with congenital heart disease
Authors' conclusion
CHD-patients have a substantially higher associated incidence of IE than the background population.
Study context
- Population
- Patients with congenital heart disease (CHD) born 1977–2018, Denmark, followed from birth to first-time infective endocarditis (IE), emigration, death or Dec 31, 2018
- Participants
- 23,464 vs 93,856
- Exposure
- CHD patients vs matched background-population controls
- CHD-patientsn = 23,464
- Controlsn = 93,856reference
- Outcome
- First-time infective endocarditis (IE)
- Follow-up
- Median 17.7 years
Methodological detailsobservational, age- and sex-matched controls, Danish nationwide registries
- Observational
- Age- and sex-matched controls
- Danish nationwide registries
Main finding
As reported in the abstract
Incidence of IE
| Group | Value | Incidence rate per 10,000 person-years |
|---|---|---|
| CHD-patients | 0.9% | 5.2 (95%CI 4.6-6.0) |
| Controls | 0.0% | 0.02 (95%CI 0.01-0.1) |
Value
CHD-patients0.9%
Controls0.0%
Incidence rate per 10,000 person-years
CHD-patients5.2 (95%CI 4.6-6.0)
Controls0.02 (95%CI 0.01-0.1)
Observational data: associations, not effects.
Further findings
IE incidence by CHD type
- Greatest incidence with tetralogy of fallot, malformations of the heart chambers (incl. transposition of the great arteries, univentricular heart, truncus arteriosus), atrioventricular septal defects and heart valve defects
Factors associated with IE among CHD-patients
- Male sex, cyanosis, cardiac prostheses, CKD and cardiac implantable electronic devices associated with IE
- Cox-regression analysis
Original publication
Long-term incidence of infective endocarditis among patients with congenital heart disease. Am Heart J. Published 19 January 2023. doi:10.
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