Arrhythmias in congenital heart disease: A nationwide cohort study
Main finding · ArrhythmiasResult — go to the resultHazard ratio 16.4 95% CI 14.4–18.7Authors' conclusion
Patients with CHD are at significantly higher risk of arrhythmias than the background population, and those with complex CHD are at particularly high risk. In patients with CHD, arrhythmia is associated with an increased risk of death.
Study context
- Population
- Danish patients with congenital heart disease (CHD) born from 1977 to 2024, followed from birth to March 2024matched cohort
- Participants
- 45,820 vs 183,280
- Exposure
- Patients with CHD vs matched background-population controls
- CHDn = 45,820
- Controlsn = 183,280reference
- Outcome
- Arrhythmias
- Follow-up
- Median 21.5 years
Methodological detailsage- and sex-matched controls, registry-based
- Age- and sex-matched controls
- Registry-based
Main finding
As reported in the abstract
Hazard ratio
16.4
95% CI 14.4–18.7
By group
CHDvs Controls
HR 16.4 (95% CI 14.4–18.7)
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| Death associated with arrhythmia (within CHD)Arrhythmiavs No arrhythmiaPatients with CHD | 6.9 (5.9–8.1) | |
| 0.10.31310Hazard ratio (log scale) |
- Most common arrhythmias in CHD
- 0.4 [95% CI 0.4-0.4] · Advanced atrioventricular block, incidence rates (IR) per 1,000 PY · Atrial flutter/fibrillation, IR per 1,000 PY 0.5 [95% CI 0.5-0.6]
Arrhythmia risk by CHD type
- Highest risk with malformations of the heart chambers, transposition of the great arteries, tetralogy of Fallot and atrioventricular septal defect; risk with ASD not negligible
Original publication
Arrhythmias in congenital heart disease: A nationwide cohort study. Am Heart J. Published 2 September 2024. doi:10.
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