Valvular & structural heart disease
Long-term outcome of bicuspid aortic valve disease
Authors' conclusion
BAV disease is associated with a high rate of cardiac events, but state-of-the-art care results in good survival with low rates of infective endocarditis, aortic dissection, and sudden death. Incremental degrees of AS and regurgitation, the presence of aortic dilatation, and age are predictive of cardiac events.
Study context
- Population
- Consecutive patients with bicuspid aortic valve (median age 29 years, 157 female)
- Participants
- 581 patients
- Outcome
- Event-free survival (cardiac events) and overall survival
- Follow-up
- 1, 2, 5 and 10 years
Methodological detailsconsecutive patients, heart valve clinic follow-up programme
- Consecutive patients
- Heart valve clinic follow-up programme
Main finding
As reported in the abstract
1, 2, 5 and 10 years
- Overall survival at 10 years
- 94.5%
- Event-free survival at 1 year
- 97%
- Event-free survival at 2 years
- 94%
- Event-free survival at 5 years
- 87%
- Event-free survival at 10 years
- 73%
- Patients developing an indication for surgery during follow-up
- 158
Observational data: associations, not effects.
Further findings
Independent predictors of events (multivariable analysis)
- AS, subdistribution hazard ratio (SHR) per degree of severity
- 2.3
- Aortic regurgitation (AR), SHR per degree of severity
- 1.5
- Baseline aortic dilatation ≥ 40 mm, SHR
- 1.9
- Age, SHR
- 1.3
- P < 0.001
Original publication
Long-term outcome of bicuspid aortic valve disease. Eur Heart J Cardiovasc Imaging. Published 15 November 2023. doi:10.
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