Heart failure & cardiomyopathies
Long-Term Outcomes: Beta-Blocker Use and Permanent Pacing in Patients With Heart Failure Preserved Ejection Fraction
Authors' conclusion
The findings of this large retrospective cohort study suggest that use of beta-blockers and permanent pacing are each associated with a lower risk of mortality in patients with HFpEF.
Study context
- Population
- Patients admitted with heart failure with preserved ejection fraction (HFpEF) to 11 hospitals of the Northwell Health system over 3.5 years22,308 in postdischarge analysis
- Participants
- 27,848 patients
- Exposure
- Permanent pacemaker (PPM) and beta-blockers vs neither
- Beta-blockersn = 9,881
- Outcome
- All-cause mortality
- Follow-up
- Median 1.5 years [0.6-2.5 years]
Methodological detailsmulticentre
- Multicentre
Main finding
As reported in the abstract
Hazard ratio (95% CI)
PPM32% lower risk
0.68(0.57–0.80)
Beta-blockers20% lower risk
0.80(0.72–0.89)
Observational data: associations, not effects.
Original publication
Long-Term Outcomes: Beta-Blocker Use and Permanent Pacing in Patients With Heart Failure Preserved Ejection Fraction. JACC Adv. Published 16 December 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →