Valvular & structural heart diseaseMeta-analysis
Long-Term Outcomes in Moderate and Severe Aortic Stenosis According to Extent of Cardiac Damage
- Pooled analysis of 2 single-centre registries
Authors' conclusion
Ten-year mortality in patients with moderate and severe AS is importantly determined by CD extent. AVR was associated with lower mortality in patients with moderate AS and advanced CD.
Study context
- Population
- Patients with moderate or severe aortic stenosis (AS), 2009–2023moderate 343, severe 283
- Participants
- 626 patients
- Comparison
- Moderate vs severe AS by extent of cardiac damage
- Outcome
- All-cause mortality
- Follow-up
- 10 years
Pooled result
As reported in the abstract
10-year mortality
Each group vs moderate AS, early CDAdjusted hazard ratio (95% CI)
Severe AS, early CD
1.42(0.75–2.72)
Moderate AS, advanced CD
1.91(1.22–2.97)
Severe AS, advanced CD
2.77(1.73–4.45)
Further pooled results
| Outcome | aHR (95% CI) | |
|---|---|---|
| Mortality with AVR vs conservative management, by CD extent and AS severity — AVR vs Conservative management · advanced CD, moderate AS | 0.43 (0.28–0.66) | |
| Mortality with AVR vs conservative management, by CD extent and AS severity — AVR vs Conservative management · advanced CD, severe AS | 0.27 (0.18–0.39) | |
| Mortality with AVR vs conservative management, by CD extent and AS severity — AVR vs Conservative management · early CD, severe AS | 0.29 (0.10–0.86) | |
| Mortality with AVR vs conservative management, by CD extent and AS severity — AVR vs Conservative management · early CD, moderate AS | 0.61 (0.25–1.44) | |
| 0.10.31310Adjusted hazard ratio (log scale) |
- Mortality with aortic valve replacement (AVR) vs conservative management, by cardiac damage (CD) extent and AS severity: 344 patients (54.9%) underwent AVR at a median 347 days
Original publication
Long-Term Outcomes in Moderate and Severe Aortic Stenosis According to Extent of Cardiac Damage. JACC Cardiovasc Interv. Published 27 October 2025. doi:10.1016/j.jcin.2025.08.018
Summarised from the published abstract; every number is checked against it