Arrhythmias & electrophysiology
Long-term outcomes of abandoned leads of cardiac implantable electronic devices
Authors' conclusion
Patients with a single AL showed similar risks of CIED-related infections, venous thrombosis/stenosis, and all-cause mortality as those without ALs, whereas those with multiple ALs showed increased risks of infection and all-cause mortality.
Study context
- Population
- Patients with cardiac implantable electronic devices (CIEDs), single-centre registry of 2962 procedures, 1984–2018matched cohort
- Participants
- 130 vs 260
- Exposure
- Abandoned leads vs no abandoned leads
- ALn = 130
- Controln = 260reference
- Outcome
- CIED-related infection, venous thrombosis/stenosis and all-cause mortality
- Follow-up
- Mean 11.2 ± 8.2 years
Methodological detailssingle-centre, matched (2 controls per AL patient)
- Single-centre
- Matched (2 controls per AL patient)
Main finding
As reported in the abstract
AL vs ControlAdjusted hazard ratio (95% CI)
CIED-related infection
2.52(0.77–8.25)
Venous thrombosis/stenosis
1.18(0.25–5.64)
All-cause mortality
1.26(0.89–1.80)
- Overall events: CIED-related infection
- 14 (3.6%)
- Overall events: venous thrombosis/stenosis
- 7 (1.8%)
- Overall events: all-cause mortality
- 143 (36.7%)
Observational data: associations, not effects.
Further findings
| Outcome | aHR (95% CI) | |
|---|---|---|
| Infection and all-cause mortality, multiple ALs vs controls (subgroup)Multiple ALsvs ControlInfection | 8.61 (2.13–34.84) | |
| Infection and all-cause mortality, multiple ALs vs controls (subgroup)Multiple ALsvs ControlAll-cause mortality | 2.42 (1.17–5.00) | |
| 0.050.21520Adjusted hazard ratio (log scale) |
Cause of abandonment
- Lead malfunction most common cause
- 64.6%
- AL group had more comorbidities than controls
Original publication
Long-term outcomes of abandoned leads of cardiac implantable electronic devices. Heart Rhythm. Published 4 August 2023. doi:10.
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