Long-Term Outcomes of Cardiac Resynchronization Therapy in Patients With Repaired Tetralogy of Fallot: A Multicenter Study
Authors' conclusion
In patients with tetralogy of Fallot treated with CRT consistent improvement in QRS duration, left ventricular ejection fraction, New York Heart Association functional class, and reasonable long-term survival were observed.
Study context
- Population
- Patients with repaired tetralogy of Fallot treated with cardiac resynchronization therapy (CRT)
- Participants
- 44 patients12 centres
- Outcome
- Early and late efficacy (LVEF, QRS duration, NYHA class), survival and safety of CRT
- Follow-up
- 3 months, 1 year and ≥2 years after CRT implantation
Methodological detailsobservational, multicentre
- Observational
- Multicentre
Main finding
As reported in the abstract
LVEF, QRS duration, NYHA class after CRT vs baseline
- Left ventricular ejection fraction (LVEF), median, baseline → early follow-up (3 months): 32% [24%-44%] → 42% [32%-50%]
- P<0.001
- LVEF remained improved from baseline thereafter
- P≤0.002
- QRS duration, baseline → early follow-up: 180 [160-205] ms → 152 [133-182] ms
- P<0.001
- QRS duration remained decreased at intermediate and late follow-up
- P≤0.001
- NYHA class significantly improved at each time point vs baseline
- P≤0.002
Observational data: associations, not effects.
Further findings
Transplant-free survival · 3, 5 and 8 years after CRT implantation
- Transplant-free survival at 3 years
- 85%
- Transplant-free survival at 5 years
- 79%
- Transplant-free survival at 8 years
- 73%
LVEF and QRS duration in upgraded CRT (subgroup; 29 [65.9%] with prior RV pacing) · each time point
- Consistent improvement in LVEF and QRS duration
- P ≤ 0.004
Original publication
Long-Term Outcomes of Cardiac Resynchronization Therapy in Patients With Repaired Tetralogy of Fallot: A Multicenter Study. Circ Arrhythm Electrophysiol. Published 12 February 2024. doi:10.
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