Long-term outcomes of chronic coronary syndrome worldwide: insights from the international CLARIFY registry
Authors' conclusion
This description of the spectrum of chronic coronary syndrome patients shows that, despite high rates of prescription of evidence-based therapies, patients with both angina and prior MI are an easily identifiable high-risk group who may deserve intensive treatment.
Study context
- Population
- Patients with chronic coronary syndrome, CLARIFY registry (enrolled November 2009 to June 2010)
- Participants
- 32,703 patients45 countries
- Exposure
- Male vs Female
- Outcome
- CV death or non-fatal MI
- Follow-up
- 5 years
Methodological detailsinternational, 45 countries
- International
- 45 countries
Main finding
As reported in the abstract
- Overall 5-year rate
- 8.0% (95% CI 7.7-8.3)
Observational data: associations, not effects.
Further findings
| Outcome | Angina | No angina | P value |
|---|---|---|---|
| Primary outcome by angina, patients with prior MI (subgroup) | 11.8% (95% CI 10.9–12.9) | 8.2% (95% CI 7.8–8.7) | P < 0.001 |
| Primary outcome by angina, patients without prior MI (subgroup) | 6.3% (95% CI 5.4–7.3) | 6.4% (95% CI 5.9–7.0) | P > 0.99 |
- Primary outcome by angina, patients with prior myocardial infarction (MI) (subgroup): interaction angina × prior MI P = 0.0016
Independent predictors of the primary outcome (Cox model)
- Main independent predictors: prior hospitalization for HF, current smoking, AF, living in Central/South America, prior MI, prior stroke, DM, current angina, PAD
Prescription of evidence-based secondary prevention therapies
- Prescription rates were high
Original publication
Long-term outcomes of chronic coronary syndrome worldwide: insights from the international CLARIFY registry. Eur Heart J. Published 3 September 2019. doi:10.
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