Long-term outcomes of high bleeding risk patients undergoing percutaneous coronary intervention: a Korean nationwide registry
Authors' conclusion
Among patients undergoing PCI, those with HBR were at increased long-term risk for both bleeding and ischaemic events, with a greater risk of mortality compared to non-HBR patients.
Study context
- Population
- Patients with stable angina or ACS undergoing percutaneous coronary intervention (PCI) in Korea, 2009–2018
- Participants
- 325,417 patients
- Exposure
- High bleeding risk (HBR) vs non-HBR
- HBRn = 66,426
- Outcome
- Co-primary: major bleeding events and ischaemic events (cardiac death, MI, ischaemic stroke)
Methodological detailsKorean National Health Insurance Review and Assessment Service database
- Korean National Health Insurance Review and Assessment Service database
Main finding
As reported in the abstract
follow-up period
HBR
- Major bleeding
- 23.9%
- Ischaemic events
- 33.8%
non-HBR
- Major bleeding
- 8.9%
- Ischaemic events
- 14.4%
Major bleeding
HBR23.9%
non-HBR8.9%
Ischaemic events
HBR33.8%
non-HBR14.4%
HBR vs non-HBRHazard ratio (95% CI)P value
Major bleeding
3.12(3.04–3.21)
P < 0.001Ischaemic events
2.50(2.45–2.56)
P < 0.001Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| All-cause mortality | 3.73 (3.66–3.79) | P < 0.001 | |
| 0.20.5125Hazard ratio (log scale) |
Average annual major bleeding rate within first year after PCI, by single HBR criterion
- Single major criterion
- 5.5%
- Single minor criterion
- 2.9%
Original publication
Long-term outcomes of high bleeding risk patients undergoing percutaneous coronary intervention: a Korean nationwide registry. Eur Heart J. Published 23 July 2024. doi:10.
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