Heart failure & cardiomyopathiesCohort study
Long-term prognosis in Takotsubo syndrome compared to heart failure: observations from a global federated research network
- retrospective observational study
- TriNetX global federated research network
- 1:1 propensity score matching
Authors' conclusion
TTS is associated with lower risk of adverse events than HF. Further research is needed on mental health in its pathogenesis and prognosis.
Study context
- Population
- Adult patients (≥18 years) discharged with a diagnosis of TTS or heart failure (HF) between 2018 and 2022TTS 2,240 · HF 265,564
- Exposure
- TTS vs HF
- Outcome
- 3-year risk of all-cause death, major adverse cardiovascular events (MACE) (myocardial infarction or ischaemic stroke), and acute HF
- Follow-up
- 3 years
Main finding
As reported in the abstract
Hazard ratio
0.622
95% CI 0.539–0.717
TTS vs HF
HR 0.622 (95% CI 0.539–0.717)
Observational data: associations, not effects.
Secondary outcomes
| Outcome | HR (95% CI) | |
|---|---|---|
| Secondary outcomes — TTS vs HF · ventricular arrhythmias · after PSM | 0.637 (0.441–0.919) | |
| Secondary outcomes — TTS vs HF · malignant arrhythmias · after PSM | 0.656 (0.571–0.754) | |
| Secondary outcomes — TTS vs HF · new-onset AF · after PSM | 0.672 (0.517–0.875) | |
| Secondary outcomes — TTS vs HF · myocardial infarction · after PSM | 0.818 (0.687–0.974) | |
| 0.512Hazard ratio (log scale) |
Subgroup by HF phenotype
- Differences were greater when TTS was compared with heart failure with reduced ejection fraction
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Long-term prognosis in Takotsubo syndrome compared to heart failure: observations from a global federated research network. ESC Heart Fail. Published 27 February 2026. doi:10.1093/eschf/xvag065
Summarised from the published abstract; every number is checked against it