Long-term prognostic impact of complete revascularisation defined by CT-derived fractional flow reserve
Authors' conclusion
Complete revascularisation defined by CT-derived fractional flow reserve was associated with a sustained reduction in cardiovascular death and spontaneous myocardial infarction over 7 years, supporting its potential role as a non-invasive tool to guide revascularisation strategies in stable coronary artery disease.
Study context
- Population
- Patients with new-onset stable angina and at least one coronary stenosis of 30% or greater on coronary CT angiography
- Participants
- 900 patients
- Exposure
- Complete versus incomplete revascularisation determined by coronary CT angiography-derived fractional flow reserve (FFR CT )
- Incompletely revascularisedn = 210
- Completely revascularisedn = 167reference
- Normal physiologyn = 523reference
- Outcome
- Composite of:
- Cardiovascular death
- Spontaneous myocardial infarction
- Follow-up
- Median of 7 years
Main finding
As reported in the abstract
Hazard ratio (95% CI)P value
Incompletely revascularisedvs completely revascularised
2.33(1.23–4.42)
P = 0.01Incompletely revascularisedvs normal physiology
3.54(2.16–5.81)
P < 0.001Observational data: associations, not effects.
Original publication
Long-term prognostic impact of complete revascularisation defined by CT-derived fractional flow reserve. Heart. Published 3 December 2025. doi:10.
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