Heart failure & cardiomyopathiesCohort study
Long-Term Rate of Heart Failure in Patients with Autoimmune Disease: A Nationwide Cohort Study
- Nationwide cohort study
- matched cohort
- Danish nationwide registries
Authors' conclusion
Patients with AID, irrespective of the type, had a higher associated rate of HF compared to the background population.
Study context
- Population
- Individuals diagnosed with an autoimmune disease in Denmark, 2000–2021median follow-up 7.9 years
- Participants
- 272,959 vs 1,091,836
- Exposure
- AID vs matched background population
- AIDn = 272,959
- Matched individualsn = 1,091,836reference
- Outcome
- Rate of HF
Main finding
HF · 10-year cumulative incidence
Hazard ratio
1.55
95% CI 1.52–1.59
By group
AID vs Matched individuals
HR 1.55 (95% CI 1.52–1.59)
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| Incident HF by individual AID (subgroup) — Systemic sclerosis vs Matched individuals · highest relative rate | 3.31 (2.63–4.16) | |
| Incident HF by individual AID (subgroup) — Addison's disease vs Matched individuals | 3.03 (2.35–3.91) | |
| 0.20.5125Hazard ratio (log scale) |
Incident heart failure (HF) by individual AID (subgroup)
- Higher rate of HF with each AID; not statistically significant for Reiter's and Behcet's disease
Original publication
Long-Term Rate of Heart Failure in Patients with Autoimmune Disease: A Nationwide Cohort Study. Eur J Heart Fail. Published 9 December 2024. doi:10.1002/ejhf.3541
Summarised from the published abstract; every number is checked against it