Valvular & structural heart diseaseCohort study
Risk of Ischemic Stroke After Patent Foramen Ovale Closure
- Population-based cohort study
- nationwide Danish registries
- birth year and sex-matched comparison cohort
Authors' conclusion
The 4-year risk of ischemic stroke after routine PFO closure for cryptogenic stroke was comparable to that observed in clinical trials, but remained higher than in the general population.
Study context
- Population
- Patients with patent foramen ovale (PFO) closure in Denmark, 2008–2021
- Participants
- 1,162 vs 11,620
- Exposure
- PFO closure vs general population
- PFO closuren = 1,162
- General populationn = 11,620reference
- Outcome
- Ischemic stroke
- Follow-up
- Within 4 years after PFO closure
Main finding
As reported in the abstract
Absolute risk of ischemic stroke · 4 years
PFO closure vs General populationAbsolute risk difference (95% CI)
Absolute risk of ischemic stroke
2.1%(0.9%–3.3%)
PFO closure vs General populationAdjusted hazard ratio (95% CI)
weighted Cox regression
6.3(3.1–12.6)
Observational data: associations, not effects.
Further findings
| Outcome | PFO closure | General population |
|---|---|---|
| Absolute risk of ischemic stroke · 1 year | 1.4% (95% CI 0.8%–2.3%) | 0.1% (95% CI 0.0%–0.1%) |
| Absolute risk of ischemic stroke · 2 years | 1.4% (95% CI 0.8%–2.3%) | 0.2% (95% CI 0.2%–0.4%) |
| Absolute risk of ischemic stroke · 3 years | 2.2% (95% CI 1.3%–3.5%) | Not reported in the abstract |
Original publication
Risk of Ischemic Stroke After Patent Foramen Ovale Closure. J Am Coll Cardiol. Published 8 October 2024. doi:10.1016/j.jacc.2024.07.015
Summarised from the published abstract; every number is checked against it