Valvular & structural heart disease
Suture-Mediated Patent Fossa Ovalis Closure: Late Clinical Outcomes and Predictors of Technical Success
Authors' conclusion
Suture-mediated PFO closure demonstrates long-term safety and efficacy. The LASSO score is a valuable tool for optimizing patient selection for this procedure.
Study context
- Population
- Patients with patent fossa ovalis (PFO)-associated stroke or transient ischemic attack undergoing suture-mediated PFO closureconsecutive patients, 2016–2023
- Participants
- 703 patients
- Outcome
- Recurrent cerebrovascular events:
- Stroke
- Transient ischemic attack
- Follow-up
- Median clinical 4 years
Methodological detailsconsecutive patients
- Consecutive patients
Main finding
As reported in the abstract
- No recurrent cerebrovascular events (stroke or transient ischemic attack) were reported
Observational data: associations, not effects.
Further findings
Independent predictors of significant residual shunt (multivariable analysis)
| Estimate | P value | ||
|---|---|---|---|
| PFO maximum width | OR per 1 mm increase 1.34 (95% CI 1.19–1.50) | P < 0.001 | |
| Minimum PFO length | OR per 1 mm increase 0.92 (95% CI 0.86–0.98) | P = 0.015 | |
| Atrial septal aneurysm | OR 1.83 (95% CI 1.14–2.91) | P = 0.011 | |
| Grade 3 Valsalva shunt | OR 2.19 (95% CI 1.25–3.90) | P < 0.007 | |
| 0.20.5125Ratio (log scale) |
Residual shunt · median transthoracic echocardiography follow-up time of 11.5 months
- Among the 703 patients, showed residual shunt
- 91
Length, Aneurysm, Severe Shunt, Opening (LASSO) score discrimination (internal validation)
- Area under the curve
- 0.73; 95% CI: 0.68-0.78
- Internally validated
Safety
Atrial fibrillation · median clinical follow-up of 4 years
- Transient episode of atrial fibrillation
- 1
Original publication
Suture-Mediated Patent Fossa Ovalis Closure: Late Clinical Outcomes and Predictors of Technical Success. JACC Adv. Published 11 July 2025. doi:10.
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