Arrhythmias & electrophysiology
Long-term survival following transvenous lead extraction: unpicking differences according to sex
Main finding · Long-term mortalityResult — go to the resultHazard ratio 1.58 CI 1.23–2.02Authors' conclusion
Female patients undergoing TLE have more favourable long-term outcomes than males with lower long-term mortality. Similar factors influenced mortality in both groups.
Study context
- Population
- Consecutive patients undergoing transvenous lead extraction (TLE) at a reference centre, 2000–2019392 died (34.2%)
- Participants
- 1,151 patients
- Exposure
- Male vs female patients undergoing TLE
- Malen = 834
- Outcome
- Long-term mortality
- Follow-up
- mean 66-month follow-up
Methodological detailssingle-centre, consecutive patients, Clinical data prospectively collected
- Single-centre
- Consecutive patients
- Clinical data prospectively collected
Main finding
As reported in the abstract
Hazard ratio
1.58
CI 1.23–2.02
P < 0.001
Events by group
Male
37.4%
312 of 834
Malevs Female
HR 1.58 (CI 1.23–2.02); P < 0.001
Observational data: associations, not effects.
Further findings
Age at explant
Predictors of mortality, female cohort
| HR (CI) | P value | ||
|---|---|---|---|
| Age > 75 years | 3.45 (1.99–5.96) | P < 0.001 | |
| eGFR < 60 | 1.80 (1.03–3.11) | P = 0.037 | |
| Increasing co-morbidities | 1.29 (1.06–1.56) | P = 0.011 | |
| 0.20.5125Hazard ratio (log scale) |
| Outcome | HR (CI) | P value | |
|---|---|---|---|
| Predictors of mortality, female cohortLVEF per percentage increase | 0.97 (0.95–0.99) | P = 0.005 | |
| 0.512Hazard ratio (log scale) |
Mean
| Outcome | Male | Female |
|---|---|---|
| Co-morbidity burden | 2.14 | 1.27 |
| LVEF | 43.4 (SD 14.0) | 50.8 (SD 12.7) |
- Age at explant: P < 0.001
- Co-morbidity burden: P < 0.001
- Left ventricular ejection fraction (LVEF): P = 0.001
Predictors of mortality, male cohort
- The same factors influenced mortality in males; HRs were lower
Original publication
Long-term survival following transvenous lead extraction: unpicking differences according to sex. Europace. Published 19 July 2023. doi:10.
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