Longitudinal Control of Lipid Levels in Patients With Premature Coronary Artery Disease
Authors' conclusion
We found low rates of longitudinal lipid target achievement in patients with premature CAD. Cumulative LDL-C exposure, but not lowest achieved LDL-C, was associated with risk of MACE.
Study context
- Population
- Patients with premature coronary artery disease (CAD) (males <50 years, females <55 years, coronary stenosis >50%)68% ACS
- Participants
- 476 patients
- Outcome
- Longitudinal attainment of guideline-recommended lipid goals and outcomes (MACE)
- Follow-up
- 3 years after diagnosis
Main finding
As reported in the abstract
Low-density lipoprotein cholesterol (LDL-C) <1.8 mmol/L on at least 1 occasion
73.2%
Consistently in target range for 3 years after diagnosis
27.3%
High-intensity lipid-lowering therapy (LLT) at diagnosis
73.9%
Good adherence over following 3 years
43.5%
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| MACE per 1 mmol/L increase in time-weighted average LDL-C exposure | 2.02 (1.48–2.76) | |
| 0.20.5125Hazard ratio (log scale) |
- MACE per 1 mmol/L increase in time-weighted average LDL-C exposure: multivariable, adjusted for sex, age, hypertension, DM, smoking
MACE per 1 mmol/L increase in time-weighted average LDL-C exposure
- Lowest achieved LDL-C not associated with MACE
Original publication
Longitudinal Control of Lipid Levels in Patients With Premature Coronary Artery Disease. JACC Adv. Published 14 November 2023. doi:10.
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