Preventive Lipid-Lowering Therapy and Interactions With Health Care in Patients Who Develop Premature Coronary Artery Disease
Authors' conclusion
Prior to presenting with premature CAD, most patients had medical encounters, but few received LLT, demonstrating a substantial gap in prevention.
Study context
- Population
- Females <55 and males <50 years with angiographically confirmed premature coronary artery disease (CAD)plus 470 registry participants
- Participants
- 11,445 females
- Outcome
- Health care use and LLT in 3 years before presentation (administrative database)
- Follow-up
- 3 years before presentation
Methodological detailsadministrative databases and clinical registry
- Administrative databases and clinical registry
Main finding
As reported in the abstract
3 years before presentation
Eligible for lipid screening
93.3%
Had health care visits
92.2%
Received lipid-lowering therapy (LLT) dispensations
14.8%
Good adherence
5.9%
Observational data: associations, not effects.
Further findings
Predictors of receiving LLT (multivariable)
| OR (95% CI) | ||
|---|---|---|
| FemalesLess likely to receive LLT | 0.75 (0.65–0.86) | |
| Rural residentsLess likely to receive LLT | 0.75 (0.62–0.91) | |
| SmokersLess likely to receive LLT | 0.65 (0.57–0.74) | |
| 0.512Odds ratio (log scale) |
| Outcome | OR (95% CI) | |
|---|---|---|
| Presenting with ACSHigh-intensity LLTvs No LLT | 0.25 (0.19–0.38) | |
| 0.20.5125Odds ratio (log scale) |
Prevention care before presentation (clinical registry, n = 470)
- Lipids assessed
- 70.2%
- Eligible for LLT by estimated CV risk
- 55.7%
- Received treatment recommendations
- 18.9%
- Received LLT dispensations
- 12.1%
Original publication
Preventive Lipid-Lowering Therapy and Interactions With Health Care in Patients Who Develop Premature Coronary Artery Disease. JACC Adv. Published 16 October 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →